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Cardiac neural crest cells : ウィキペディア英語版
Cardiac neural crest cells
Neural crest cells are a group of temporary, multipotent (can give rise to some other types of cells but not all) cells that are pinched off during the formation of the neural tube (precursor to the spinal cord and brain) and therefore are found at the dorsal (top) region of the neural tube during development.〔Kirby M. ("Cardiac morphogenesis: recent research advances." ) ''Pediatric Research.'' 1987 21(3) 219 - 224.〕 They are derived from the ectoderm germ layer, but are sometimes called the fourth germ layer because they are so important and give rise to so many other types of cells.〔〔Gilbert S. F. ("Developmental biology." ) Sinauer Associates, Massachusetts, 2010 p373 - 389.〕 They migrate throughout the body and create a large number of differentiated cells such as neurons, glial cells, pigment-containing cells in skin, skeletal tissue cells in the head, and many more.〔〔
Cardiac neural crest cells (CNCCs) are a type of neural crest cells that migrate to the circumpharyngeal ridge (an arc-shape ridge above the pharyngeal arches) and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT).〔〔〔Kuratani S. C. and Kirby M. L. "Migration and distribution of circumpharyngeal crest cells in the chick embryo: formation of the circumpharyngeal ridge and E/C8+ crest cells in the vertebrate head region." Anat. Rec. October 1992 234(2) p263 - 268 pmid 1384396 doi 10.1002/ar.1092340213〕
They extend from the otic placodes (the structure in developing embryos that will later form the ears) to the third somites (clusters of mesoderm that will become skeletal muscle, vertebrae and dermis).〔〔
The cardiac neural crest cells have a number of functions including creation of the muscle and connective tissue walls of large arteries; parts of the cardiac septum; parts of the thyroid, parathyroid and thymus glands. They differentiate into melanocytes and neurons and the cartilage and connective tissue of the pharyngeal arches. They may also contribute to the creation of the carotid body, the organ which monitors oxygen in the blood and regulates breathing.〔〔
== Pathway of the migratory cardiac neural crest cell ==


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